0.9% Sodium Chloride Injection indications for various reasons caused by water loss, including hypotonic, isotonic and hypertonic water loss; Hyperosmolar non-ketotic diabetic coma, isoosmolar or hypoosmolar sodium chloride can correct the water loss and hyperosmolar state; Hypochloric metabolic alkalosis; External use of physiological saline to wash eyes, wash wounds, etc. It is also used in obstetrics to induce labor by water sac.
Drug properties
This product is a clear colorless liquid; Taste salty.
Pharmacology
Sodium chloride is an electrolyte supplement drug. Sodium and chlorine are important electrolytes in the body, which mainly exist in the extracellular fluid and play a very important role in maintaining normal blood and extracellular fluid volume and osmotic pressure. Normal serum Na+ concentration is 135-145 mmol/L, accounting for 92% of plasma cation and 90% of total osmotic pressure, so plasma sodium level plays a decisive role in osmotic pressure. Normal serum Cl- concentration is 98~106mmol/L. Sodium and chloride ions in human body are mainly regulated by hypothalamus, posterior pituitary and kidney to maintain the stability of body fluid volume and osmotic pressure.
Drug interaction
When used as a drug solvent or diluent, attention should be paid to the incompatibility between drugs.
Adverse Reactions
Too much and too fast infusion can cause water and sodium retention, edema, increased blood pressure, accelerated heart rate, chest tightness, dyspnea, and even acute left heart failure.
Too much or too fast hypotonic sodium chloride can cause hemolysis and cerebral edema.
Product Specification 50ml,100ml,250ml,500ml,1000ml
Medication for pregnant women
Pregnancy hypertension syndrome is contraindicated.
Medication for Children
The amount and speed of fluid replenishment should be strictly controlled. [Medication for elderly patients] The amount and speed of fluid replacement should be strictly controlled.
1. Hypertonic water loss When hypertonic water loss occurs, the osmotic concentration of brain cells and cerebrospinal fluid increases. If the sodium concentration and osmotic concentration of plasma and extracellular fluid decrease too quickly after treatment, brain edema can be caused. Therefore, it is generally believed that plasma Na+ concentration decreased by no more than 0.5mmol/L per hour in the first 48 hours of treatment. (1) The following conditions should be used with caution :
Edematous diseases, such as nephrotic syndrome, cirrhosis, ascites, congestive heart failure, acute left heart failure, cerebral edema and idiopathic edema, etc.
Acute renal failure oliguria stage, chronic renal failure urine volume reduction and poor response to diuretics;
Hypertension;
Hypokalemia.
(2) Check the concentration of sodium, potassium and chloride ions in serum according to clinical needs;
Blood acid-base concentration balance index, renal function and blood pressure and cardiopulmonary function.
Mass fraction :9g/L
Concentration :153.8mmol/L
Osmotic concentration :307.7mmol/L
Physiological phenomenon The plasma volume of the body increased, and the corresponding amount of NaCl and water were excreted and returned to the level before injection
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