| State: | Liquid |
|---|---|
| Transport Package: | 10 Vials/Box |
| Specification: | 80mg/2ml |
| Trademark: | TENAS |
| Origin: | China |
| Samples: |
|---|
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Audited Supplier Product Name:Gentamycin Sulfate Injection
Ingredient:Gentamycin Sulfate
Character:Colorless or almost colorless clear liquid.
Indication:
This product is used in the treatment of sensitive gram-negative bacilli, such as e. coli, klebsiella species, e. coli and proteus, Mr Charest bacteria genera, pseudomonas aeruginosa and staphylococcus methicillin sensitive strains caused by severe infection, such as sepsis, lower respiratory tract infection, intestinal infection, pelvic infection, abdominal cavity infection, skin soft tissue infection, complexity, urinary tract infections, etc. When treating abdominal cavity infection and pelvic cavity infection, it should be combined with anti-anaerobes, and gentamicin and other antibacterial drugs should be used in clinic. Enterococcal infections are treated with penicillin (or ampicillin). It is also used for infection of the central nervous system caused by sensitive bacteria, such as meningitis and ventricular inflammation, which can be treated by intrathecal injection.
Usage:
1. Intramuscular injection or diluted intravenous infusion for adults, 80mg (80,000 units) once, or 1-1.7mg/kg according to body weight, once every 8 hours; Or 5mg/kg once every 24 hours. The course of treatment is 7-14 days. A single dose of 50-200ml of 0.9% sodium chloride injection or 5% glucose injection should be added to the intravenous drip once a day, so that the concentration of the liquid does not exceed 0.1%. The solution should be slowly dropped within 30-60 minutes, so as to avoid neuromuscular blockade.
2. Intramuscular injection or intravenous drip after dilution, 2.5mg/kg, once every 12 hours; Or 1.7mg/kg once every 8 hours. The course of treatment is 7-14 days, during which blood concentrations should be monitored as much as possible, especially in newborns or infants.
3. Intrathecal and intraventricular administration doses were 4-8mg once for adults and 1-2mg once for children (over 3 months), once every 2-3 days. During injection, the liquid was diluted to a concentration not exceeding 0.2% and then was pumped into a 5ml or 10ml sterile syringe. After lumbar puncture, a considerable amount of CEREBROspinal fluid was first injected into the syringe. All the liquid was slowly injected within 3-5 minutes while being pumped and pushed.
4. Dosage for patients with decreased renal function: once every 8 hours for those with normal renal function, the normal dose is 1-1.7mg/kg, and the creatinine clearance rate is 10-50ml/min, once every 12 hours, the dosage is 30-70% of the normal dose; When creatinine clearance was <10ml/min, 20-30% of the normal dose was given every 24-48 hours.
Adverse reactions:
1, the process of medication may cause hearing loss, tinnitus or full sense of the ear and other ototoxicity, affect the vestibular function can occur instability, vertigo. Hematuria may also occur, the number of micturition significantly reduced or urine volume reduced, anorexia, extreme thirst and other renal toxicity. Low incidence of neuromuscular block or nephrotoxicity caused by dyspnea, lethargy, weakness and so on. Occasionally, skin rash, nausea, vomiting, liver dysfunction, leukopenia, granulocytopenia, anemia, hypotension, etc.
2. In a small number of patients, hearing loss, tinnitus or fullness in the ear and other ototoxicity symptoms may occur after drug withdrawal, which should be noticed.
3. Systemic administration combined with intrathecal injection may cause leg convulsions, rash, fever and systemic spasm, etc.
Taboo:This product or other aminoglycosides allergy is contraindicated.
Attention:
1. This product should be used with caution in the following cases: water loss, the eighth to cerebral nerve damage, myasthenia gravis or Parkinson's disease and renal function damage.
2. Cross-allergy. Patients who are allergic to an aminoglycoside antibiotic such as streptomycin and amikacin may be allergic to this product.
3. Routine urine and renal function should be measured regularly before and during medication to prevent serious renal toxicity. If necessary, audiometry or electrocardiogram, especially high-frequency audiometry, and temperature stimulation test are performed to detect vestibular toxicity.
4. When conditions are available, the blood drug concentration should be monitored during the course of treatment, and the dose should be adjusted accordingly, especially for newborns, the elderly and patients with renal dysfunction. For one dose every 8 hours, the effective plasma concentration should be maintained at 4-10 g/ mL, avoiding peak concentration exceeding 12 g/ mL and valley concentration remaining at 1-2 g/ mL. For one dose every 24 hours, the peak blood concentration should be maintained at 16-24 g/ mL and the valley concentration should be <1 g/ml. Intrathecal injection should also be monitored for drug concentration in the CSF.
5. If the blood concentration cannot be determined, the dose should be adjusted according to the measured creatinine clearance rate.
6. After the first saturation dose (1-2mg/kg), the maintenance dose for patients with renal insufficiency, vestibular function or hearing loss should be reduced.
7. Patients should be given enough water to reduce the damage of renal tubules.
8. Long-term application may lead to excessive growth of drug-resistant bacteria.
9. Not suitable for subcutaneous injection.
10. This product has inhibitory effect on respiration. Intravenous injection is not allowed.
11. Interference to diagnosis: This product can increase the measured values of alanine aminotransferase (ALT), aspartate aminotransferase (GOT), serum bilirubin concentration and lactate dehydrogenase concentration; Serum calcium, magnesium, potassium, and sodium concentrations may be reduced.
Drug interaction:
1. Combined with other aminoglycosides or successive local or systemic application may increase the possibility of ototoxicity, nephrotoxicity and neuromuscular blockade.
2. When combined with neuromuscular blockers, neuromuscular blockade can be aggravated, resulting in muscle weakness, respiratory depression and other symptoms.
3. Combined with capreomycin, cisplatin, etanilic acid, furtimox or vancomycin (or norvancomycin), or successive local or systemic application may increase ototoxicity and nephrotoxicity.
4, with cefthiophene, cefazolin local or systemic combined may increase renal toxicity.
5. In combination with polymyxin injections or in successive local or systemic applications, nephrotoxicity and neuromuscular blockade can be increased.
6. Other nephrotoxic and ototoxic drugs should not be combined with this product or applied successively, so as to avoid aggravating nephrotoxicity or ototoxicity.
7. Aminoglycosides and lactams (cephalosporins and penicillins) may cause mutual inactivation when mixed. When used in combination with the antibiotics mentioned above, the product must be administered by bottle infusion. It is also not recommended to drip with other drugs in the same bottle.
Storage:
Shading, sealed storage .
Expiry date:24 months
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• Product file in CTD or standard format
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We are a group of professional pharmaceutical manufacturing personnel, accumulated rich experience in production, quality and management.
We offer a wide of quality products covring Tablet, Capsule, Soft gel Caps, Syrups, Injectables, Infusions, Ointments, Protein powder, Nutraceutical Combinations and Herbal Combinations in very attractive & elegant packs.
With the efforts of all members, the products are exported to Africa, South America, Central America, Middle East countries, as well as some southeast Asian countries.
Safety, Purity, Efficacy and Accuracy of ingredients are often some of the salient features of our medicines. Each product is made using top-ranked ingredients and ingredients under the supervision of a medical expert. Our organization is fortunate to have highly skilled professionals who devote significant expertise and experience to leading organizations in providing the highest quality medicines.
More than 200 products have been registered outside China. Our factories are established according to GMP standards and have passed MOH tests in more than 20 countries.
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