Product Description
Product information
Product name: Citicoline injection
Specification: 1g/4ml
Package: 5 ampoules/tray/box
Shelf life: 36 months
1 What CITICOLINE injection is and what it is used for
PHARMACOLOGICAL PROPERTIES:
PHARMACODINAMICS
Citicoline, being the precursor of key ultrastructural components of a cellular membrane (mainly phospholipids), possesses wide range of activities, promotes restoration of the damaged cell membranes, inhibits action of phospholipases, what prevents excessive formation of free radicals and destruction of cells, affects the mechanisms of apoptosis. In the acute period of stroke it reduces the volume of damaged tissue, improves cholinergic transmition. In head injury it reduces duration of a post-traumatic coma and intensity of neurologic symptoms. Citicoline improves observed during hypoxia symptoms, such as memory impairment, emotional liability, lack of initiative, difficulties at conducting of daily actions and self-service. The drug product does not influence breath, pulse and arterial pressure; therefore long treatment is possible.
PHARMACOKINETICS
As Citicoline is natural compound which is found in organism, it is impossible to provide classical pharmacokinetic research in connection with complexity of quantitative analysis of exogenous and endogenous
Citicoline.
INDICATIONS:
1. Disturbance of consciousness associated with head injury or brain surgery.
2. Promotion of rehabilitation of the upper extremities in patients with hemiplegia following cerebral apoplexy.
3. Treatment in combination with anticholinergics in the following cases of parkinson's disease, in which tremor is especially severe:
- Cases in which adverse reactions have developed under treatment with L-DOPA.
- Cases in which the administration of L-DOPA is difficult because of laparotomy or complication.
- Cases in which L-DOPA is ineffective.
4.Concomitant therapy with protease inhibitors in the treatment of the following diseases:
- Acute pancreatitis.
- Acute exacerbation of chronic recurrent pancreatitis.
- Acute pancreatitis after surgery.
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